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Merck & Co., Inc. announced a voluntary withdrawal of Vioxx (rofecoxib) from the U.S. and worldwide market due to safety concerns of an increased risk of cardiovascular events (including heart attack and stroke) in patients on Vioxx. Prior to withdrawal of Vioxx, the following side-effects had been noted:
· upset stomach
· dizziness
· heartburn
· vomiting
· constipation
· bloody vomit
· bloody diarrhea or black, tarry stools
· swelling of the face, hands, feet, ankles, or lower legs
· unexplained weight gain
· fatigue, unusual tiredness
· yellowing of the skin or eyes
· right upper abdominal pain
· flu-like side-effects
· skin rash
· itching
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